In Vincenzo Natali's Splice, Adrien Brody and Sarah Polley have created a MONSTER! Or just a human-animal hybrid that might not be that bad looking if we could get a little hair on her--maybe kind of an Angelina Jolie-in-Hackers thing. Depends on your definition of monster and dating standards. Here's the trailer; you decide.
This is what happens when you try to skip steps with science. Obviously make a centaur lady first, make sure she does OK, put her on a few heavy metal album covers, then move on to making whatever the fuck this thing with the tail is.