Over at IESB, an apparently reliable source has delivered a scoop about Harry Osborn's role in Spider-Man 3. So if you care about plot, and surprises and things, don't read this:
All the assumptions that Harry Osborn is the third villain the Hobgoblin are all wrong. Spiderman finds himself out numbered in this one. When everything seems to be at its worst for our hero, he finds himself an unlikely ally, Harry Osborn. We will see Harry battling his inner demons to make the choice between his father's legacy and his best friend.
This would seem to contradict the report last month that James Franco would be wearing make-up and appliances in his role, presumably as a villain. Unless instead of Goblin makeup, he just puts on random make-up and appliances when saving Spider-Man, which would make no sense.
I do, however, think that wearing random make-up would be a good idea for police and firemen saving people. That way, even if you're stuck in a burning building, afterwards you have a good story about how you were rescued by Richard Nixon and Dracula.